Jaimie Thomas played high school football at Bishop McDevitt High School in Harrisburg, PA. As a sophomore he allowed just one quarterback sack  and allowed none during his junior and senior seasons. He served as part of a blocking unit for LeSean McCoy, who, in 2003, rushed for 2,561 yards in ten games. He was a SuperPrep All-American and first-team All-State player.

During his time at the University of Maryland, he only allowed one sack in 162 plays as a freshman. The Associated Press and Atlantic Coast Sports Media Association named him an All-ACC honorable mention coming out of college. Thomas was selected in the 2009 NFL Draft by the Indianapolis Colts as the 236th overall pick.