Anthony Smith attended Syracuse University was a 3-year starter at safety and corner. At Syracuse, he was selected for First and Second Team All-Big East. He finished his Syracuse career ranked third in school history with 14 interceptions. Smith also set a school record with six blocked kicks, turning two into touchdowns.

After college, Smith played 6 years in the NFL and won 2 Super Bowls with the Pittsburgh Steelers and Green Bay Packers Packers. He also played with the Tennessee Titans, Jacksonville Jaguars and St. Louis Rams. Smith retired from professional football in 2012.